Comorbidities of Prurico nodularis

Prurico nodularis is often accompanied by psychological and physical ailments. These aspects must be taken into account for the success of the treatment.

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Prurigo nodularis (PN) is a chronic inflammatory skin disease characterized by hyperkeratotic, dome-shaped, highly pruritic papules and nodules varying in size from a few millimeters to centimeters. PN is associated with chronic comorbidities such as atopic dermatitis, type 2 diabetes, hypertension, chronic kidney disease (CKD), chronic liver disease (CLD), and thyroid disease. Psychological complications also occur frequently, leading to a significant reduction in quality of life.

In a recent retrospective study by Tagaddos et al* based on patient files, demographic and clinical characteristics and comorbidities of patients affected by PN were analyzed. In addition, the efficacy of systemic therapies including methotrexate, cyclosporine, and narrow-band ultraviolet (NB-UVB) was examined in patients enrolled in the study.

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