Comorbidities of Prurico nodularis

Prurico nodularis is often accompanied by psychological and physical ailments. These aspects must be taken into account for the success of the treatment.


Prurigo nodularis (PN) is a chronic inflammatory skin disease characterized by hyperkeratotic, dome-shaped, highly pruritic papules and nodules varying in size from a few millimeters to centimeters. PN is associated with chronic comorbidities such as atopic dermatitis, type 2 diabetes, hypertension, chronic kidney disease (CKD), chronic liver disease (CLD), and thyroid disease. Psychological complications also occur frequently, leading to a significant reduction in quality of life.

In a recent retrospective study by Tagaddos et al* based on patient files, demographic and clinical characteristics and comorbidities of patients affected by PN were analyzed. In addition, the efficacy of systemic therapies including methotrexate, cyclosporine, and narrow-band ultraviolet (NB-UVB) was examined in patients enrolled in the study.

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